BRT with MEBT/MEBO demonstrates that the dream of skin regeneration has come true. 

For about a century, scientists made great efforts to achieve the regeneration of injured skin.

In the early 20th century, doctors discovered that the subcutaneous tissues survive after full thickness third-degree burns and may be capable of regeneration. 

However, they did not find an adequate measure to achieve this survival and therefore they pursued research on in vitro skin cell culture and transplantation of the cultured autograft.

By utilizing the regeneration gene for skin information in the subcutaneous tissue, in concert with the creation of a favorable nurturing environment (one favorable to physiological regeneration of the skin), BRT with MEBT/MEBO successfully achieves the skin regeneration within large areas of deep burns wounds.

This achievement greatly decreased the disablement rate, and increased the survival rate of large-area burns by 50–80% (compared with the data published in 1997 and 1994).