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MEBO Scar Lotion is safe and effective in treating hyperplastic scars


Please Note: The following was automatically translated by google.

An analysis of the efficacy of MEBO Scar Lotion in treating 74 cases of hyperplastic scar post burn

GU Feng, The 4th People's Hospital, Quilin City, Guangxi Province 541001,China

【Abstract】

Objective: To observe the efficacy of MEBO Scar Lotion in treating hyperplastic scar post burn.

Method: MEBO Scar Lotion was applied 3 to 4 times a day on the scars and followed by massage for 5 to 10 minutes.

Result: 74 cases with 86 scars were treated. The curative rate was 18.6%, markedly effective rate was 53.5% and effective rate was 19.8%. Ineffective rate was 8.1%.

Conclusion: MEBO Scar Lotion is safe and effective in treating hyperplastic scars. It is easy to be popularized in outpatient clinics.

【Key words】: MEBO Scar Lotion; hyperplastic scar; prevention; treatment

我院自2000年1月至2004年12月应用美宝疤痕平防治烧伤增生性瘢痕,取得良效,报道如下:

一、一般资料
共 74例,86处创面;男45例,女29例;年龄10~63岁,平均32.4岁;深度:深Ⅱ度45处,浅Ⅲ度37处,深Ⅲ度4处。面积为0.5%~18%; 创面分布:头面16处,四肢37处,躯干25处,关节8处。其中深Ⅱ度5处、浅Ⅲ度27处、深Ⅲ度3处,共35处为早期应用MEBT/MEBO治疗创面愈 合所形成的瘢痕,余为早期应用干性治疗所形成瘢痕。

二、治疗方法与疗效

1.方法:瘢痕区皮肤用美宝疤痕平外涂,涂药前用温水清洗瘢痕皮 肤,涂药厚薄如同涂面油一样,每次涂用疤痕平后需轻轻按摩5~10分钟(刚愈合的皮肤20天内不按摩,不清洗),每日3~4次,用药时间为3个月~1年。 四肢部位在涂药后用弹力绷带加压包扎,对于瘢痕时间较长的较小面积瘢痕,每周用曲安缩松局部封闭治疗1次,共4~8次。

2.疗效评价:①治愈: 痛、痒、紧缩感消失,瘢痕松软变平,几近正常肤色,关节活动正常;②显效:痛、痒、紧缩感基本消失,瘢痕基本变松软,色明显变浅,关节活动明显改善;③有 效:痛、痒、紧缩感明显减轻,瘢痕一定程度萎缩,颜色变淡,关节功能有所改善;④无效:痛、痒、紧缩感无明显减轻或加重,瘢痕色泽、范围无明显改变、关节 功能无改善。
3.治疗效果:采用MEBT/MEBO治疗后形成的35处瘢痕中,治愈10处,占28.57%,显效20处,占57.14%,有效3 处,占8.57%,无效2处,占5.71%;采用干性疗法形成的51处瘢痕中,治愈6处,占11.76%,显效20处,占50.98%,有效14处,占 27.45%,无效5处,占9.8%。用弹力绷带包扎、曲安缩松局部封闭注射处瘢痕好转较快,无效病例中均是瘢痕形成半年以上者,占此类患者的 33.33%。

三、讨论
    瘢痕形成的机制目前尚未完全清楚,一般认为瘢痕的形成是由于机体炎性反应,胶原的合成与降解不平衡,异常粘多糖的出现以及肌成纤维细胞的增生造成。增生性 瘢痕实际为胶原纤维显著增生且排列紊乱。胶原纤维为胶原按一定极性排列聚合成的胶原纤维再进一步聚合而成。成纤维细胞是胶原合成的主要细胞,而肌成纤维细 胞具有成纤维细胞和平滑肌细胞的特征和功能,在创伤愈合过程中及瘢痕组织增生时肌成纤维细胞大量增生并与成纤维细胞之间相互转化,除保持纤维细胞合成胶原 蛋白、基质和胶原的功能外,还具有收缩功能,使瘢痕组织挛缩变硬。动物试验和临床实践中已证实:抑制成纤维细胞的增生和胶原合成能防治瘢痕。而增生性疤痕 和正常愈合的非增生性瘢痕的重要区别是胶原纤维的排列异常,前者胶原纤维呈弧状或漩涡状排列,恢复它的平行整齐,就意味着瘢痕的消褪和治愈[1]。美宝疤 痕平特有的油酸、甾醇、酪胺、仙人掌精、蜂蜡精等成分,在具有抑制纤维细胞作用的同时还能促进表面细胞的增殖,并能促使瘢痕的胶原纤维重新排列,从而达到 预防和消除瘢痕的目的[2]。

在临床运用过程中,我们体会美宝疤痕平还有如下优势:

1.治疗瘢痕的痛、痒、紧缩感疗效好,起效快。特别是痒感,患者常因搔抓破溃反复感染而致瘢痕加重。美宝疤痕平能有效改善瘢痕组织中微血管壁及神经末梢缺氧,患者多在涂药1分钟至10分钟内症状明显减轻或消失。

2. 对传统干性治疗烧伤创面和对用MEBT/MEBO治疗的创面形成的增生性瘢痕均有效,而对用MEBT/MEBO治疗后形成的增生性瘢痕疗效最好。因为使用 MEBT/MEBO治疗烧伤会减轻瘢痕,较少需要瘢痕相关治疗和二期整形治疗,这不仅在国内得到公认,在国外也已得到证明[3]。

MEBO对创面作用为 “原位再生”,创面再生组织较符合人体正常生理状态,各组织细胞按比例生长,排列较有序,易于调控。

3.对传统用弹力绷带局部加压和局部注射曲安缩松疗效差或无效的病例,用美宝疤痕平仍有部分疗效较好;反之,美宝疤痕平治疗增生性瘢痕时配合使用弹力绷带加压包扎及局部注射曲安缩松,能达到增进疗效的效果。

参 考 文 献
[1]蔡景龙,张宗学.现代瘢痕治疗学[M].一版,北京:人民卫生出版社, 1998:48..[2]徐荣祥.再生医学研究[M].一版,北京:中国医药科技出版社,2002: 95.
[3]毕莎拉.阿提叶,等.湿润烧伤膏的成本——效益分析[J].中国烧伤创疡杂志,2004,16(1):75~76.

【作者简介】
古风(1967~),男(汉族),广西桂林人,1990年广西医科大学毕业,主治医师,科主任.

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