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High capacity and effects in controlling wound infections of MEBO in treating wounds and ulcers

1. Isolate wound, and reduce contamination:

As is well known, there are two sources of different kinds of wound infections: 

  • one is contamination from extraneous sources, mainly including the microorganism invasion in the air and medical pollutions; 
  • the other is contamination from internal source, mainly referring to the bacterial infection inside the human body. 

Generally, there are about 1000 aerobic bacteria and semi-aerobic bacteria in 1 cm2 of normal skin, accounting for 1~10% of the total bacteria in the human body. 

There are anaerobic bacteria and semi-anaerobic bacteria in the visceral organs in the human body, accounting for 90~99% of the total bacteria. 

These inside and outside florae are called "normal florae" in non-pathogenic conditions. 

When the environment and conditions change, there forms flora imbalance, resulting in systemic or local infection. 

After MEBO is applied on the wound, its two-layer structure covers the wound tightly, isolate the environmental pollution, and reduce the invasion of external bacteria, so as to achieve the objective of isolating wound and abating pollution.

2. Unobstructed draining, bacteria removal: 

MEBO forms automatic liquid flow circulation in the wound tissues, remove the bacteria in the wound tissues in the condition of unobstructed draining, so as to decrease the bacterial concentration in the wound, control the bacterial infection from inside, relieve or get rid of systematic and local bacterial infection, and abate the invasion of anaerobic bacteria and semi-anaerobic bacteria

3. Destroying the existing and reproduction environment of bacteria:

As is well known, aerobic bacteria and semi-aerobic bacteria can live and reproduce well in a humid environment, while anaerobic bacteria and semi-anaerobic bacteria can live and reproduce well in a humid environment with no oxygen or little oxygen.

So long as this existing condition is destroyed, the bacteria cannot live. 

MEBT and MEBO block the supply of nutrition, water and oxygen which are essential for bacteria, destroy the existing condition of bacterial by binding MEBO with the wound necrotic tissues through the lipophilic function of MEBO, so that various bacteria cannot survive in the wound and the ointment, and they are removed from the wound through the inducing flow excretory function of the ointment. 

As a result, the local and systemic bacterial infections are controlled. This method is completely different from dry therapy: moist environment is favorable for the regeneration of tissue cells.

Especially, the regeneration action is very obvious in the cells impending death. 

Moreover, this environment is harmful for bacteria, so that MEBO has specific function of anti-infection.

4. Direct or indirect bactericidal and bacteriostatic functions:

Although the bactericidal effects and the bacteriostatic actions of MEBO are weak, when it is used together with other active ingredients, such as phellodendron bark ester oil, it has direct bactericidal effects and bacteriostatic actions, and can reduce bacteria and control infections.

In total, the manifestation of the anti-infection effect of MEBO is as follows: It has important functions of blocking bacteria, inhibiting bacteria, removing bacteria, and destroying the existing conditions of bacteria. 

Therefore, MEBT and MEBO have strong capacity in controlling infections.

Although only weak bacteriostatic and bactericidal effects were observed in the experiments, its powerful infection control capacity could be proved by the clinical practice.

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