What is a
physiological moist environment and why can MEBT/MEBO create such an
environment?
Physiological
moist environment refers to a kind of physiological environment with
the same pH value, colloid osmotic pressure and crystal osmotic
pressure as the interstitial fluid, i.e. a physiological environment
favorable for cell growth.
The physiological moist environment is created by MEBT/MEBO through the following aspects:
MEBO is composed of 30 natural nutrients such as protein,
amino acids, polysaccharides and microelements which are concocted
according to the standard ratio of interstitial fluid so that the
consistent pH value, colloid osmotic pressure and crystal osmotic
pressure are obtained.
When the wounds were protected by MEBO & fibrous isolation membrane (FIM) (see
Q12-13, Part1), the evaporation of the water in the burns wound tissue
is approximately the same as that of the normal skin. This membrane
protects the injured wounds and helps wound respiration. This is quite different from dry therapy and vaseline treatment;
there are a lot of data to show that the burns wounds neither lose so
much water as treated with dry therapy and the tissues nor suffocated
and macerated as treated with Vaseline [11-15].
Standard application of MEBT/MEBO to eliminate the
excessive exudation, burns toxin, bacteria and liquefied necrotic
tissues timely from the burns wound, keeping the wound clean throughout
the treatment;
After the thorough removal of necrotic tissues from the
deep burns wound, it forms a FIM on the wound with the same
characteristics and functions as “semi-permeable" membrane,
enabling the exchanges of all compositions by ion contraflow. The
metabolites of the wound can be excreted to the ectosexine of the
membrane by osmosis. Through the same mechanism, MEBO regenerative
nutrient substances can permeate the membrane to provide nutrition to
tissue cells in the deep layer of the wound, so that a physiologically
moist environment is created.
Reference:
[11] ‘Moist Exposed Burn Therapy: Evaluation of the Epithelial
Repair Process (an Experimental Model)’, Ioannovich J, Tsati E,
Tsoutsos D, et al.; Annal of Burns and Fire Disasters 2000: XIII (J):3-9
[12] ‘The Effect of MEBO on Maintaining a Physiological Moist
Environment in Treating Burn Wound’, Xie EF, Xu RX, Wang CC, et
al. Annal of Burns and Fire Disasters 2002: XV (3): 102-124
[13] ‘Maintain Wound in a Physiological Moist Environment and
Improving Quality of Healing’, Atiyeh BS, et al. Dermatol Surg
2003 Jan; 29(1):14-20]; [Atiyeh BS, et al. European Journal of Plastic
Surgery 2003; 26(2): 5-11]
[14] ‘A Comparative Study on the Anti-shock Effect between MEBO
and Dry-Exposed Burn Therapy Using a Rabbit Model’, Xu RX., Burns
Regenerative Medicine and Therapy, 1st ed., ISBN 3-8055-7661-7, Basel:
Karger; 2004. p. 47-50
[15] ‘Clinical Study on Invisible Water Loss of Burns Wounds
Treated with BRT with MEBT/MEBO’, Xu RX., Burns Regenerative
Medicine and Therapy, 1st ed., ISBN 3-8055-7661-7, Basel: Karger; 2004.
p. 53-55
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