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Burn Regenerative Medicine and Therapy

Regeneration is an instinct of human beings.

For the longest time people have been exploring the frontiers of science and technology to look for materials and means to maintain health, to prevent, treat diseases, and to live a long, productive life.

The key to reaching these goals lies in the regeneration of tissues and organs in the face of aging, infection of pathogens, and environmental insults.  

Regeneration maintains or restores the original, physiological structure and function of the tissues and organs in the body. 

"Regenerative Medicine" is an innovative concept and it describes a distinct way of functional tissue and organ regeneration. 

In the 1970s, in China, Professor Xu Rong Xiang alone was thinking outside of the box where he boldly established an entirely new theory of burns physiology upon which he then built a dramatically effective burns treatment which he called ‘Burns Regenerative Therapy’ (BRT)

This innovation, which integrates moist-exposed burns treatment (MEBT) and moist-exposed burns ointment (MEBO), was a balm to the struggling burns therapy industry.

The therapeutic essence of MEBT/MEBO is to maintain the burns wound in an optimum physiologically moist environment through the use of a specially designed ointment – MEBO.

Rather than surgically excising the burned tissue and its underlying dermis, the goal became to heal the burned tissue and stack the cards in favor of tissue regeneration – an unimagined goal.

MEBO, the patented topical remedy, is composed of natural plant extracts dissolved in a sterile and refined sesame-oil base with beeswax as a preservative.

When applied topically, MEBO promotes burns tissue repair in an astonishingly effective manner. 

Initially, MEBO cleans the burned tissue by stimulating the discharge and removal of debris (liquefaction of necrotic tissues). 

As a complementary healing benefit, MEBO also enhances the regeneration and repair of the residual viable tissue at the base and periphery of the burn in order to anchor vitality within the wound-healing process.

Coincident with the application of MEBO, a systemic comprehensive treatment is initiated based on the natural pathophysiology of burned tissue.

Accordingly, BRT and MEBT/MEBO is distinguished from conventional surgical therapy in that dry-ness, excision, skin grafting and scarring as well as the excruciating pain associated with dressing changes is no longer a necessary component of burns care.

What is Regenerative Medicine?

1. Surgical burns therapy was a major method of burns treatment Before BTR with MEBT/MEBO was invented.

Common Problem: Skin Burns
burn is such a common problem that almost everybody has been burned to a more or less degree in their lives..

Skin Structure and Function
Skin is the body's largest organ, and one of the most complex. 3 layers: epidermis,dermis and subcutis

Skin Grafting
A skin graft is a surgical procedure in which a piece of skin is transplanted from one area to another

Surgical Excision and Skin Grafting Therapy
Surgical burns therapy should no longer be the major method of burns treatment after Burn Regenerative Thearpy was invented.

2. Pathogenesis Of Burns Wounds

Burns are systemic complex injuries following skin exposure to thermal energy. 

Here, we focus on the local pathogenesis of burns when and after thermal injuries occur to disclose the pathogenic basis and rationale of local therapeutics.

Following thermal injury, skin undergoes three injury phases in pathogenic order:

Physical injury of Burns Wounds
includes direct and indirect physical injury

Biochemical injury
Local biochemical injury begins within 1 h of the thermal insult and lasts for up to approximately 72 h post-burn

At 72 h postburn, the wound tissue comes into a phase of rejection reaction

3. Pathological of Burns Wounds

Pathological changes after burns consist of injury pathology, repair pathology and physiology according to the changes of local wound.

The injury pathological focus mainly refers to pathomorphological changes following thermal injury of skin while repair pathology and physiology refers to auto-repairing pathological and physiological changes of injured skin.

4. Trerapeutics for local treatment of Burn Medicine and Therapy

Dry and dehydrated state vs. physiologically moist state ?

Surgical Excision and Skin Grafting Therapy
dry and dehydrated stare: a purely surgical technique and functions with disregard to burns physiology

Therapeutics of Burns Regenerative Medicine and Therapy with MEBT/MEBO
MEBT was invented on the basis of a series of burns natural pathogeneses, appreciating each aspects of burns tissue’s physiological response including physical, chemical and biochemical reactions.

5. BRT gain Serveral Breakthrough and Benefit for Burn Patients
greatly decreased disablement rate, increase survival rate of large-area burns by 50-80%, resolve the problem of pain, relieve the economic and mental load of the burns victims, etc

6. Skin Organ Can Regeneration and Reparation in Situ
skin regeneration is our natural abilibilty, recovery must following the natural law

7. Necrotic Tissue Liquefaction on Burn Wound without further damage

The liquefaction of the necrotic tissue on burn wound is a requirement for wound skin reparation and regeneration in situ

The necrotic tissues on burn wound are liquefied and discharged without further damage must be applied under the strict standards and practice of MEBT/MEBO

The basic treatment principle is to reserve and protect the active tissue cells surviving in burn wound basis, so that the interbiotic tissues can be resuscitated under the physiologically moist environment, which ensures the wound repair and regeneration.

8. The Mechanism of Regenerative Reparation of Burn Wounds In situ
There are three requirements for skin regenerative repair of burn wounds: 
  • First of all, a physiologically moist environment should be formed in the wound;
  • secondly, there should have histological basis for in situ cultivation of skin keratin type 19 stem cell and material basis for regeneration;
  • and thirdly, standardized therapeutic technique of skin regeneration medicine should be applied, in order to ensure skin regenerative repair of burn wounds.

9. Clinical Application of Regenerative Repair of Burn Wounds in Situ

10. The Formation of Burns Medical Therapy in the 21st Century

MEBO SCAReducer Lotion -- Burn Wound Scar
MEBO SCAReducer Lotion -- Burn Wound Scar
Natural SCAR Reducer for hypertrophic scar, acne scar,keloid scar,sunken scar, and other scards caused by surgery, burns,scald,dertmatits, cosmetics......
An innovative natural product that treats various burns of any depth and any size: accelerates healing, inhibits bacterial growth, has analgesic effects, and prevents scarring of wounds
MEBO Gastrointestinal Capsule--Repair & Regeneration of Mucosa of the Gastrointestinal (GI) Tract
MEBO Gastrointestinal Capsule--Repair & Regeneration of Mucosa of the Gastrointestinal (GI) Tract
Repair & Regeneration of Mucosa of the Gastrointestinal (GI) Tract, Peptic Ulcer, Gastroduodenal Ulcer,etc
Enhancing absorption of nutrients from food

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