Regenerative Medicine and Therapy
Regeneration is an instinct of
For the longest time people have been exploring
the frontiers of science and technology to look for materials and means
to maintain health, to
prevent, treat diseases, and to live a long, productive life.
The key to reaching these goals lies in the
regeneration of tissues and organs in the face of aging, infection of
pathogens, and environmental insults.
maintains or restores the original, physiological structure and
function of the tissues and organs in the body.
an innovative concept and it describes a distinct way of functional
tissue and organ regeneration.
In the 1970s, in China, Professor Xu Rong Xiang
alone was thinking outside of the box where he boldly established an entirely new theory of burns
physiology upon which he then built a dramatically
effective burns treatment which he called ‘Burns Regenerative
This innovation, which integrates moist-exposed burns
treatment (MEBT) and moist-exposed burns
ointment (MEBO), was a balm to the struggling burns therapy
The therapeutic essence of MEBT/MEBO is to
maintain the burns wound in an optimum physiologically moist environment
through the use of a specially designed ointment – MEBO.
Rather than surgically excising the burned tissue
its underlying dermis, the goal became to heal the burned tissue and
stack the cards in favor of tissue regeneration – an
MEBO, the patented topical remedy, is composed of
extracts dissolved in a sterile and refined sesame-oil base with beeswax
as a preservative.
When applied topically, MEBO promotes burns
tissue repair in an astonishingly effective manner.
Initially, MEBO cleans the burned tissue by
stimulating the discharge and removal of debris (liquefaction
of necrotic tissues).
As a complementary healing benefit, MEBO also
enhances the regeneration
of the residual viable tissue at the base and periphery of the burn in
order to anchor vitality within the wound-healing process.
Coincident with the application of MEBO, a
systemic comprehensive treatment is initiated based on the natural pathophysiology
of burned tissue.
Accordingly, BRT and MEBT/MEBO is distinguished
in that dry-ness, excision, skin grafting and scarring as well as the
excruciating pain associated with dressing changes is no longer a
necessary component of burns care.
|What is Regenerative Medicine?
Surgical burns therapy was a major method of burns treatment Before BTR
with MEBT/MEBO was invented.
Problem: Skin Burns
burn is such a common problem that almost everybody has been burned to
a more or less degree in their lives..
A skin graft is a surgical
in which a piece of skin is transplanted from
one area to another
Pathogenesis Of Burns Wounds
Burns are systemic complex injuries
following skin exposure to thermal energy.
Here, we focus on the local pathogenesis of
and after thermal injuries occur to disclose the pathogenic basis and
rationale of local therapeutics.
Following thermal injury, skin undergoes three injury phases in
Local biochemical injury begins within 1 h of the thermal insult and
lasts for up to approximately 72 h post-burn
At 72 h
postburn, the wound tissue comes into a phase of rejection
Pathological of Burns Wounds
Pathological changes after burns consist of injury pathology, repair
pathology and physiology according to the changes of local wound.
The injury pathological focus mainly refers to pathomorphological
changes following thermal injury of skin while repair pathology and
physiology refers to auto-repairing pathological and physiological
changes of injured skin.
Trerapeutics for local treatment of Burn Medicine and Therapy
dehydrated state vs. physiologically moist state ?
BRT gain Serveral Breakthrough and Benefit for Burn Patients
greatly decreased disablement rate, increase survival rate of
large-area burns by 50-80%, resolve the problem of pain, relieve the
economic and mental load of the burns victims, etc
Skin Organ Can Regeneration and Reparation in Situ
skin regeneration is our natural abilibilty, recovery must following
the natural law
| 7. Necrotic
Tissue Liquefaction on Burn Wound without further damage
The liquefaction of the necrotic
tissue on burn wound is a requirement for wound skin reparation
and regeneration in situ.
necrotic tissues on burn wound are liquefied and discharged without further damage
must be applied under the strict standards
and practice of MEBT/MEBO.
treatment principle is to reserve
and protect the active tissue cells surviving in burn
wound basis, so that the interbiotic tissues can be resuscitated under
the physiologically moist environment, which ensures the wound repair
The Mechanism of Regenerative Reparation of Burn Wounds In situ
are three requirements for skin
regenerative repair of burn wounds:
- First of all, a physiologically
moist environment should be formed in the wound;
- secondly, there should have histological
for in situ cultivation of skin keratin type 19 stem cell and material
basis for regeneration;
- and thirdly, standardized therapeutic
of skin regeneration medicine should be applied, in order to ensure
skin regenerative repair of burn wounds.
Clinical Application of Regenerative Repair of Burn Wounds in Situ
Formation of Burns Medical Therapy in the 21st Century