Diagnosis of first-degree burns is the same as the conventional surgical standard. 

The burns wound is ery-thematous in appearance, has no blister, may be painful and have slight swelling. 

These wounds typically heal spontaneously by 3 days postburn with varying degrees of epithelial exfoliation. 

The injured area should not be included when estimating the total extent of the burn since, pathologically speaking, the skin was only thermally irritated and not burned, as there was no structure injury to epidermal basal layer and no formation of zone of stasis. 

MEBO can accelerate the recovery of first-degree burns with resolution of erythematous skin within 24 h and immediate cessation of pain. 

The injured epithelia in the superficial layer of epidermis can be exfoliated and removed together with the MEBO and no systemic reaction occurs.