Burn is a systemic disease caused by thermal injury. 

The changes in topical treatment directly affect the systemic pathophysiological status. 

BRT with MEBT/MEBO systemic treatment is essentially different from conventional surgical dry therapy. 

While using BRT with MEBT/ MEBO, the protocol of surgical dry therapy is forbidden. 

Two principles should be followed in this treatment on extensive deep burns: 

1. In the early stage, a comprehensive antishock treatment principle is applied, which involves enhancing cardiac function, protecting renal function and supplementing effective blood volume according to the vital signs. 

2. In the middle and later stages, expectant treatment is applied, with a protocol of keeping a water-electrolyte balance, nutritional support and maintaining a comprehensive balance. 

In the anti-infection treatment, a large dose of strong and powerful broad-spectrum antibiotics should be used in the early stage for 7–10 days and then withdrawn immediately, in order to protect and enhance the anti-infective function of the internal organs. 

For nutritional supporting treatment, a protocol of oral administration is desired.