The solid necrotic tissues can be changed to liquid form (Liquefaction), and then discharged from the wound under the effect of MEBO. 

Before we annotate the process of liquefaction, we need to introduce the pharmacological effect of the special frame form of MEBO (low melting point). 

This frame form is alterable depending on the change of wound temperature: MEBO is an ointment at Room Temperature.

After applied onto the wound for the thickness of 1mm, there are two layers of MEBO: 

• the outer side of MEBO keeps "ointment form" 
• the wound-touched side is wanned up and transformed to liquid form. 

MEBO has the lipophilic character. 

After applying, the liquid fonn MEBO reacts with necrotic tissues on burn wound, and then MEBO loses the lipophilic character and mixes with exudation and liquefactive stuff, then the mixture moves to the outer layer of MEBO and be discharged out of skin. 

The new upper layer of MEBO continues to be warmed up and transformed to liquid form and then Hydrolysis, Enzymolysis, Rancidity, Saponification and Esterification happen sequentially, repeatedly and drainage automatically. 

This is the main mechanism of liquefaction of burn wound necrotic tissue.

A. MEBO is warmed up and surrounds necrotic tissues: 

First, the grease base of solid form MEBO is wanned up by wound temperature and be transformed to liquid form.

The oil is released and flows into the burn wound, divides the necrotic tissue into pieces and surrounds them.

It will initiate the series chemical reactions between MEBO and necrotic tissues.

B. Hydrolysis: 

The first reaction is hydrolysis (One compound is decomposed under the effect of water.) 

The remain water in necrotic tissues react with the necrotic skin under the effect and surrounding of MEBO, which will further initiate the series chemical reactions.

C. Enzymolysis: 

There are kinds of zymngens in remnant cells in burn wound necrotic tissues. Zymngens are the non-activate prosome of enzymes. 

After hydrolysis, the peptide of the zymngen in charge of the non-active function is removed. 

Then the big molecules such as protein, fat, carbohydrate are digested into small molecules by several kinds of enzymes. 

Thus, the necrotic tissue on burn wound is changed into molecular level.

D. Rancidity and saponification: 

Based on organic chemistry, acid and alkali chemical reactions are the reactions that obtain or lose electron (s). 

Rancidity reaction means that the amino acids, fatty acids are separated, the aldehyde keton oxide are formed from protein, fat tissues after the above-mentioned reactions. 

All these acidity compounds are composed by hydrogen ion and acid radical. 

These organic acids produce neutral salt and water after decomposion and combination. 

Saponification means the fat hydrolyzes in the alkalescence solution and produces glycerol and fatty acids.

burns can make the wound tissue denaturalized and necrosis, produce lots of histamine, bradykinin, lactic acid, free radical and other acid substances, which are called "Burn toxin". 

Under the therapeutical effect of MEBO, the burn toxins are decomposed, so that the direct damage of the wound are relieved; more addition, it reduces die damages of multi organs in the body by absorption of burn toxins. 

In one word, the result of rancidity and saponification is to decompose the necrotic tissue into neutral substances, which will protect the wound efficiently and alleviate the damage of burn toxins after absorption.

• not only the correct and standardized application of BRT is a requirement in local wound,
• but also the procedures and techniques of systemic BRT, thiey assistant to each other.