Firstly apply MEBO to protect exposed bone. 

One week later, clean necrotic periosteum and cortical bone. Drill on the surface of exposed bone deep to medullary substance every 0.5-1 centimeter. Cover wounds with gauze soaked by MEBO. Redress 2-3 times every day. Culture granulation tissue at these drills. 

After exposed bone was covered by granulation tissue, transplant skin to cover wounds. 

1. The clinical manifestations of burn wounds on shinbone of leg.
 

 
2. Clean necrotic tissues on the surface of bone tissues.
 

 
3. Clean the surface of bone with scraper or bone file.
 

 
4. Drill on bone with distance of 1mm, deep to medullary substance and with some blood.
 

 
5. The picture of finished drilling.

 
6. Cover wounds with gauze soaked by MEBO. 7 days later, granulation tissues grow out of drills.

7. Continue applying MEBO. 25 days later, granulation tissues grow and extend covering exposed bone tissues.
Transplant skin to cover wounds.