Clinical signs include wound pain, extensive blisters, wound without blister skin becoming red and white, the superficial dermal tissue is necrotic and turns white, the surviving deep dermis tissue is red, while under pressure it turns white and soon returns to red after release of pressure (DIID burns wounds respond more slowly). 

The exu-dates of the wounds are only less than those of superficial second-degree burns.

BRT with MEBT/MEBO treatment and clinical manifestation: It is a four-period process: 

• firstly, treatment in the early stage (shock period), same as that for superficial second-degree burns; 
• secondly, liquefaction and rejection period of necrotic dermal tissue (rejection period); 
• thirdly, regeneration and recovery period, and, 
• fourthly, rehabilitation period of skin physiological function after wound healing.
  

First Period. 

The treatment of the first period is the same as that for 
superficial second-degree burns, emphasizing on wound protection. A thin layer of soft membrane may appear on the wound free of putrid or blistered skin. The next treatment period starts on day 4–5 post-burn when the wound edema diminishes gradually.

Second Period. 

Clean away the putrid skin, blistered skin or thin soft membrane in the same way as dealing with superficial second-degree burns. Continue the application of MEBO. Gradually, the necrotic layer of wound surface begins to liquefy from the superficies to the interior and produces white liquefied products floating over the wound surface. 

Usually at 3–4 h after application of MEBO, the wound is totally covered with whitish liquefied products, indicating that MEBO is consumed completely. 

The liquefaction products must be cleaned away before the renewal of MEBO. Another 3–4 h later, the renewed MEBO is consumed again when the liquefaction products float over the wound. 

Clean the liquefaction products, renew MEBO again and keep the clean-renew-clean process going until the necrotic tissues are entirely liquefied and discharged. This process generally occurs 5– 15 days postburn. Patients with large-area burns are urged to turn over during drug renewal.

Third Period. 

After the second period treatment, the chestnut-like residual dermis tissues, millet-sized, are exposed on the basal layer of the wound. Continue MEBO with less thickness directed under BRT with MEBT/ MEBO and renew every 4–5 h (every 6–8 h at night). Covered and protected by MEBO, the residual dermal tissue reconstructs and regenerates. Once dermis tissue regenerates to smooth skin, less irritation to the wound is allowed. Again reduce dosage and renewing times as long as the wound is not dry, but crust formation is forbidden, i.e. not only prevent wounds from being macerated by MEBO, but also avoid the wounds becoming dry and getting covered by a crust. Duly keep the normal skin around the wound clean. For large-area burn patients, do as in the second period by helping them turn over regularly on the basis of drug change intervals. The pressured parts of the body still need MEBO protection till the wounds heal. This period occurs 15–20 days postburn.

Fourth Period. 

Although the wound heals after the third stage, the functions of the newly healed skin still need to rehabilitate completely. The epidermis requires further physiological adjustment and metabolism; the sebaceous glands need compensatory metabolism; the excretory duct of the sweat gland is not yet clear; the functions of pigment cells are unable to meet the requirements of normal skin. Under these circumstances, MEBO is still necessary to be used as a skin-care oil for another 10–15 days. Or apply newly developed MEBO series products – MEBO Cleansing Cream to promote quicker recovery of skin function, or apply MEBO Itch Relieving Cream to stop itching.

Deep Second Degree Superficial Burns Clinical signs include wound pain, extensive blisters, skin at the wound without blister skin becoming red and white, necrotic or white superficial dermal tissue, and red survival deep dermis tissue. 

A thin layer of soft membrane may appear on the wound. 

Reserve the layer of membrane and continue applying MEBO every 4-5 hours evey day. 

Five days later, clean the membrane and redress complying with the principle of "Three No". (Don't cause pain, Don't cause bleeding and Don't cause any further damage in the normal skin tissue)

The necrotic tissues are all liquefied and discharged from wounds 10-15 days postburn. 

20 days later, wounds regenerate and repair to heal. 

Continue applying MEBO for 10-15 days as protective oil until skin functions are restored to normal.